does blood type affect covid vaccine side effectsdoes blood type affect covid vaccine side effects
and elicited consistent side effects as compared to other COVID-19 vaccines, according to Dr. Martinello. People react differently after being vaccinated. Some previously young, healthy people who have developed COVID-19 have suffered strokes, possibly due . Published online November 24, 2020. doi:10.7326/M20-4511, Latest News Your top articles for Saturday, Continuing Medical Education (CME/CE) Courses. Of course, its not just as simple as saying that anyone with an O blood type has a lower risk of dying of COVID-19. It is not intended to provide medical advice or to take the place of such advice or treatment from a personal physician. Following incubation at 37C for 1 hour, absorbance at 405 nm was measured in the cell-free supernatants. What do I need to know about the AstraZeneca vaccine? This unusual clotting may cause different complications, including organ damage, heart attack and stroke. Thank you for submitting a comment on this article. Notably, she took danicopan throughout her first vaccination and did not experience breakthrough hemolysis. These include soreness where the jab was. Your friend would have a worse case of COVID-19 because they were infected with more virus. 14% had at least one whole-body (systemic) after-effect - such as fever, aches or chills - within seven days of the first dose, rising to about 22% after the second dose These after-effects get. The studys primary outcome was SARS-CoV-2 infection. Knowledge of your blood type is usually important if you're undergoing a blood transfusion or organ transplantbut in those situations, your medical team will test your blood type beforehand. In April, researchers at Columbia University reported similar risks associated with Type A blood after blood-typing more than 1,500 New Yorkers and testing them for COVID-19. performed research, collected and analyzed data, and wrote the first draft of the manuscript; X.Y. Lexington, MA 02421. His last dose of ravulizumab was 4 weeks prior to vaccination. Blood type O seems to have the lowest risk. Dr. DelCollo is board-certified in family medicine by the American Board of Family Medicine. Additionally on danicopan; however, 2 doses were missed immediately following vaccination. Complement has emerged as a likely driver of the immune response and end-organ damage in COVID-19. Read More Safety of COVID-19 Vaccines Some people have no side effects. Virologists and vaccine experts explore what we know below. This "Covid arm" rash can be red, itchy, swollen, or painful. We recommend vaccination within 4 weeks of the last ravulizumab infusion and 1 week of eculizumab infusion and that patients maintain optimal hydration. Thanks for visiting Infectious Disease Advisor. Gundry and Anderson and their collaborators have been collecting and studying blood and tissue samples for this collaborative research. It is not clear to me why. However, cases remain very rare: the MHRA noted 79 cases of blood clots with low platelets, including 19 deaths, following more than 20m doses of the AstraZeneca jab, with 44 of the cases and 14 of the deaths related to a rare type of blood clot in the brain called cerebral venous sinus thrombosis (CVST) that occurred with a low platelet count. In addition, COVID-19 vaccination might offer better protection than getting sick with COVID-19.A recent study showed that unvaccinated people who already . Regardless of if a specific blood type is associated with a greater risk of contracting COVID-19 and developing severe disease, keep in mind that many other factors, such as age or existing health conditions, are likely to play a larger, dominant role in determining personal risk from COVID-19. It was through these findings, that the Danish researchers suggested: "That blood group O is significantly associated with reduced susceptibility to SARS-CoV-2 infection.". The aRR for SARS-CoV-2 infection in the O blood group was 0.88 (95% CI, 0.84-0.92) vs all other blood groups, and the ARD was -3.9 per 1,000 (95% CI, -5.4 to -2.5). Quite a bit of research has been published on the topic of blood type and its role in determining COVID-19 risk. Cookies collect information about your preferences and your devices and are used to make the site work as you expect it to, to understand how you interact with the site, and to show advertisements that are targeted to your interests. However, the results have been inconsistent and so the connection between COVID-19 and different blood types still isn't clear. The question of a possible relationship between blood type and disease risk has been a topic of active research since early in the pandemic. One theory is that antibodies may play a role. In large clinical trials, most side effects have been minor. Investigators also suggested further research on how ABO status may moderate venous thromboembolism occurrence, a known complication of COVID-19, since blood group O patients have been associated with a decreased risk of venous thromboembolism in prior research. When side effects occur, they typically last just a few days. Furthermore, among ongoing clinical trials of immunotherapy using convalescent plasma or of SARS-CoV-2 vaccines, the interaction between participant blood groups and therapeutic efficacy could be measured.. Researchers found no link between blood type and COVID-19 risk, adding that more research was needed on the topic. The researchers did find evidence suggesting a relationship between blood type and COVID-19 risk. While the distribution of blood types is different in New York City than in Wuhan and Shenzhen, after controlling for other risk factors, they found that individuals with Type A blood were 34 percent more likely to test positive for the coronavirus, while having Type O or AB blood was associated with a lower probability of testing positive. Fatigue. Specifically, they sought out folks in the U.S. diagnosed and hospitalized with COVID-19. UNMC researcher Rebekah Gundry, PhD, received a "COVID-19 and Its Cardiovascular Impact Rapid Response Grant" from the American Heart Association in May of 2020. receives research funding from Alexion. The top 6 fabrics you should avoid wearing (and why), Can you reverse gray hair? Yet these risks are relative, meaning people with type O blood are not immune to COVID-19. For the AstraZeneca jab, it seems such side-effects are more common after the first shot. If so, how can I get that information? A bigail, a 29-year-old from New York City who asked to use a pseudonym to preserve her privacy, knew to expect some side effects after she got her second Pfizer-BioNTech COVID-19 vaccine in . Dr. Isaac Bogoch discusses the study that examines the risk and severity of COVID-19 and different . "Reassuring the public that everything is being done . Common side effects included: tenderness at the injection site for 73% of participants. The posts claim that the FDA warns that death is a side effect of the COVID-19 vaccines. Blood clot symptoms and when they're likely to occur. Neither Donna Gates nor Body Ecology, Inc., nor the publisher of this content takes responsibility for possible health consequences of any person or persons reading or following the information in this educational content. Annex V Some women can feel the lump, but for. If you haven't heard of the term "bivalent" just yet, it refers to the fact that this updated vaccine contains genetic code targeted to the original strain of virus that spreads COVID-19, known as SARS-CoV-2 in addition to parts of the Omicron-based strains that are circulating currently. For A and AB groups, the stay was 13.5 days. Side-effects such as fever, chills, tiredness and headache throughout the body were more common after the second dose of the vaccine, the US Centers for Disease Control said. VITT seems to occur five to 13 days after vaccination with the J&J or AstraZeneca-Oxford shots - after the normal vaccine side effects have . Perhaps having both anti-A and anti-B antibodies gives type O individuals the ability to minimize the disease. Those two factors make up the eight most common blood types: A+, A-, B+, B-, O+, O-, AB+, and AB-. You also shouldn't expect a lighter immune response, either. This difference in risk of testing positive for COVID-19 seemed to hold even when researchers took into account age, sex, body mass index, ethnicity, and co-morbidities (i.e., pre-existing conditions like heart disease and diabetes). Your friend sits next to the person infected. Those with A or AB type blood also tended to stay longer in the hospitals intensive care units (ICU). So far, most of the cases reported have occurred in women under 60 years of age within two weeks of vaccination. Ray JG, Schull MJ, Vermuelen MJ, Park A. The side effects of the three COVID-19 vaccines approved by the FDA for temporary use (Pfizer, Moderna and . Here's What You Need to Know, People With Food Allergies May Have Lower Risk of COVID-19 Infection, What To Do About a Lingering Cough After COVID, New Omicron Booster Side Effects: What to Expect From the Bivalent Vaccines. Or, they suggest, perhaps the genes associated with blood type also have some effect on the ACE2 receptor, the protein that allows the SARS-CoV-2 virus to infect human cells. Hemolysis in each sample was compared with total water-induced lysis of the erythrocytes. Omicron vs. Delta: How the 2 COVID-19 Variants Compare, ShinglesHerpes ZosterInfection May Be Linked to the COVID-19 Vaccine. Blood type O seems to have the lowest risk. In other words, the benefits of the jab far outweigh the risks. The study found that patients with blood types A and AB were found to be more likely to require mechanical ventilation and to require dialysis for kidney failure. All readers/viewers of this content are advised to consult their doctors or qualified health professionals regarding specific health questions. The data came from critically ill patients at two Vancouver hospitals, where 84 percent of those with blood type A or AB needed intubation and ventilation compared to just 61 percent of those with O or B type blood. Both of these studies were posted to the MedRxiv website, where researchers share preliminary, unpublished data, before it has undergone peer review. The most commonly reported reaction was a raised, sometimes itchy red rash, often at the site of the injection, which can occur up to a week or so after being vaccinated. This is why learning from Body Ecology, from doctors, and from other practitioners in our space is important. Why Trust Us? Erythrocyte lysis with addition of the SARS-CoV-2 spike protein S1. "The resulting brownie is the same, though.". Enjoying our content? The blood type-infection connection is not unique to the coronavirus. The other common side-effects the muscle aches, flu-like illness and fatigue are probably due to generalised activation of the immune system caused by the vaccine. Blood type may influence other infections, as well. This is the body's natural response, as it's working hard to build immunity against the disease. - Drug Monographs "I encourage people who have had COVID once, or even multiple times to still seek out vaccination, as it's going to really optimize the level of protection that you have against getting COVID yet again this fall and winter," he advises. "There is no real benefit for the individual person," said Torben Barington, DMSc, a clinical professor of immunology at the University of Southern Denmark and co-author of the early Danish study. If any of these side effects occur, they should go away in a few days. However, experts say it is too soon to be sure the J&J jab is causing the blood-clotting problem, and even if it is, the risk is very low. The blood group A was statistically significantly more frequent among those infected with COVID-19 compared to controls (57% vs. 38%, P < 0.001; OR: 2.1). We may earn commission from links on this page, but we only recommend products we back. Please login or register first to view this content. And, in fact, these researchers, like the researchers in China and New York City, found a higher risk for severe illness among individuals with Type A blood and a protective effect for Type O. The O- blood group did not appear protective against severe COVID-19 illness and death (aRR, 0.84; 95% CI, 0.64-1.07) compared with other blood groups. Blood clots in the arteries leading to the brain can cause a stroke. Copyright 2023 by American Society of Hematology, Aplastic anemia, transfusion dependence, microvascular small bowel thrombosis, renal failure, smooth muscle dystonia, Transfusion dependence, hemoglobinuria, smooth muscle dystonia, Hemoglobinuria, fatigue, extravascular hemolysis with transfusion dependence on C5 inhibition, Last dose ravulizumab prior to vaccination, Fever, myalgia, headache, fatigue, hemoglobinuria, Fever, fatigue, dark urine, vomiting, diarrhea. Americans are learning more about the new set of bivalent COVID-19 booster vaccines made by teams at Pfizer and Moderna after officials at the .css-1me6ynq{-webkit-text-decoration:underline;text-decoration:underline;text-decoration-thickness:0.0625rem;text-decoration-color:#125C68;text-underline-offset:0.25rem;color:#125C68;-webkit-transition:all 0.3s ease-in-out;transition:all 0.3s ease-in-out;}.css-1me6ynq:hover{color:#595959;text-decoration-color:#595959;}Food and Drug Administration (FDA) authorized its rollout earlier this month. ), and the Jack LevinC. pain upon and after vaccination for 60% of participants. The chances of any of these side effects occurring after vaccination differ according to the specific vaccine. Still, the study authors wrote, "the impact of blood type on clinical outcomes remains unclear. - Full-Length Features Is this true? "These side effects may affect your ability to do daily activities, but they . Hearst Magazine Media, Inc. All Rights Reserved. Even Mild COVID-19 Infections Increase Risk of Type 2 Diabetes, Research Shows, Journal of the American Medical Association, CDC guidelines to prevent the spread of COVID-19. But if you understand how vaccines work, you'll know that experiencing a side effect isn't a sign that something's gone wrong. Most side-effects are mild and short-lived, and some groups are more likely to get them than others. "There's a fairly decent amount of existing literature beyond SARS-CoV-2" that certain blood types can play a role in disease risk and severity, says Joel Ray, M.D., a clinician scientist and professor at St. Michael's . There are some theories on why there could be a link: Your red blood cells are covered with molecules that are known as antigens, Thomas Russo, MD, professor and chief of infectious disease at the University at Buffalo, told Health. A position paper from the SAAWP of the EBMT, Complement inhibition at the level of C3 or C5: mechanistic reasons for ongoing terminal pathway activity, Incomplete inhibition by eculizumab: mechanistic evidence for residual C5 activity during strong complement activation, Thrombotic events with Neisseria meningitidis vaccination in patients with paroxysmal nocturnal hemoglobinuria, UK experience [abstract], Characterization of breakthrough hemolysis events observed in the phase 3 randomized studies of ravulizumab versus eculizumab in adults with paroxysmal nocturnal hemoglobinuria, Complementopathies and precision medicine, 2021 by The American Society of Hematology. "Some evidence shows the severity of the infection is associated with different blood cell types, but the mechanisms by which it happens are unclear," says Dr. Anderson. But again, experts say it's too early to know for sure. That evidence best comes from looking at the responses from older people and younger people because the evidence is that the vaccines are very effective right across the age range, but the side-effect profile is weighted towards younger people., How UK doctor linked rare blood-clotting to AstraZeneca Covid jab, Original reporting and incisive analysis, direct from the Guardian every morning. Researchers have been talking about blood type and COVID-19 susceptibility for months. Copyright 2023 Haymarket Media, Inc. All Rights Reserved. Prior to joining GH in 2019, Zee fostered a nutrition background as an editor at Cooking Light and is continually developing his grasp of holistic health through collaboration with leading academic experts and clinical care providers. What Are Side Effects of the COVID-19 Vaccines? Immunothrombotic dysregulation in COVID-19 pneumonia is associated with respiratory failure and coagulopathy, Pulmonary vascular endothelialitis, thrombosis, and angiogenesis in Covid-19, Direct activation of the alternative complement pathway by SARS-CoV-2 spike proteins is blocked by factor D inhibition, Safety and efficacy of the BNT162b2 mRNA Covid-19 vaccine, Efficacy and safety of the mRNA-1273 SARS-CoV-2 vaccine, How I treat paroxysmal nocturnal hemoglobinuria, SARS-CoV-2 infection depends on cellular heparan sulfate and ACE2, Disturbed sialic acid recognition on endothelial cells and platelets in complement attack causes atypical hemolytic uremic syndrome, Heparan sulphate identified on human erythrocytes: a Plasmodium falciparum receptor, Anti-complement treatment for paroxysmal nocturnal hemoglobinuria: time for proximal complement inhibition? For current information about MIT Medicals services, please see relevant areas of the MIT Medical website. Side effects of the coronavirus (COVID-19) vaccination Very common side effects in the first day or two include: having a painful, heavy feeling and tenderness in the arm where you had your injection feeling tired headache, aches and chills diarrhoea, nausea and vomiting mild flu-like symptoms The authors of the NEJM study hypothesize that different combinations of A and B antigens may change how the immune system produces infection-fighting antibodies or have some other, unknown effect on how the body responds to infection. Sleep expert Dr. Michael Breus strongly advises that getting a good nights sleep is essential before you go in for the vaccine in order to build a healthy antibody response.7. Reported side effects of COVID-19 vaccines have mostly been mild to moderate and have lasted no longer thana few days. The Government guidance says, "Like all vaccines, COVID-19 mRNA Vaccine BNT162b2 [Pfizer] can cause side effects, although not everybody gets them. 2. In populations at high-risk for exposure, such as healthcare workers, essential workers, and people exposed to a known case of the disease, the O blood type had an even greater protective effect. For the primary outcome, analyses were further stratified by patients aged younger than 70 years vs 70 years or older. In populations at high-risk for exposure, such as healthcare workers, essential workers, and people exposed to a known case of the disease, the O blood type had an even greater protective effect, reducing the risk of acquiring the virus by 19 percent. Data collected by the FDA for earlier bivalent COVID-19 booster vaccines suggests that these shots successfully provided immunogenicity (a boost to your immunity!) Dr. Susan R. Bailey, an allergist, immunologist and president of the American Medical Association, said side effects develop because your immune system is reacting to the vaccine. But an even better way to get your blood type tested is to donate blood, which, by the way, is still a safe thing to do, even during a pandemic. Joint pain. Side effects are actually your body's idea - not the vaccine's. When you get a sore arm, fever or fatigue after vaccination, those reactions are your body's way of jumping into action to protect you. This seems to be an issue with DNA adenovirus vector vaccines the biology of which is yet to be fully understood, said Prof Saad Shakir, director of the independent Drug Safety Research Unit. While Health is trying to keep our stories as up-to-date as possible, we also encourage readers to stay informed on news and recommendations for their own communities by using the CDC, WHO, and their local public health department as resources. 4. Typical side effects include pain at the injection site, fever, fatigue, headache, muscle pain, chills and diarrhoea. Centers for Disease Control and Prevention, you didn't experience any side effects at all, better bolster your body's immune response, other better-for-you fluids to stay hydrated, Your Privacy Choices: Opt Out of Sale/Targeted Ads, Take over-the-counter medication like ibuprofen, acetaminophen, aspirin, and antihistamines as needed, Apply a cold compress or a wet washcloth over the injection site if experiencing redness or swelling, Exercise your arm after injection to mitigate discomfort. Briefly, type O-positive red blood cells from 1 patient with PNH and 1 control were collected. Conflict-of-interest disclosure: R.A.B. One study of over 3,000 people who got a COVID-19 vaccine did not find any increased side effects or other issues among people with different blood types. designed research, analyzed data, and wrote the manuscript; and all authors reviewed the manuscript and approved the final version. Of course, your blood type is not a risk factor over which you have any control. Investigators conducted a population-based, retrospective cohort study of 225,556 patients who had their ABO blood group assessed between January 2007 and December 2019, and subsequently tested for SARS-CoV-2 between January 15 and June 30, 2020. He has written about food and dining for Time, among other publications. Contribution: G.F.G. Youve viewed {{metering-count}} of {{metering-total}} articles this month. For blood types O and B, the average stay was nine days. According the ZOE Covid symptom study released last month and looking only at the Pfizer jab, about a third of vaccine recipients who had previously had Covid reported having a whole-body side-effect (such as chills), compared with 19% of those who had not had Covid. Registration is free. Is It Dandruff or Dry Scalp? Headache. One of the most unusual and serious side-effects of the COVID-19 vaccine jab, which has been reported from various corners is Blood clotting. - And More, Close more info about Type O and Rh-Negative Blood Type Protective Against COVID-19, Reproductive Organ Infections and Sexually Transmitted Infections, Association between ABO and Rh blood groups and SARS-CoV-2 infection or severe COVID-19 illness. Secondary outcome results indicated that type O blood group had an aRR of 0.87 (95% CI, 0.78-0.97) for severe COVID-19 illness and death versus all other blood groups and Rh- status had an aRR of 0.82 (95% CI, 0.68-0.96) compared to . A side effect or reaction isn't necessarily all bad, by the way; it may indicate that the body is building protection against the virus. This work was supported by National Institutes of Health, National Heart, Lung, and Blood Institute grants R01 HL 133113 (R.A.B.) What this means is that the white blood cells that are stimulated by the vaccine to make antibodies themselves have to secrete chemicals called cytokines, interferons and chemokines, which function to send messages from cell to cell to become activated.. Our clinicians do not order blood typing routinely, other than for pregnant patients. Association between ABO and Rh blood groups and SARS-CoV-2 infection or severe COVID-19 illness. Headache. Type A blood was associated with a 45 percent increased risk of having respiratory failure, while Type O was associated with a 35 percent reduction in risk. However, a genome-wide association study (GWAS) recently published in the New England Journal of Medicine (NEJM) is both consistent with, and potentially explains, these earlier results. But . No. The work described baseline rates of the AESIs . Some research findings have suggested that people with blood types A and AB are more susceptible to contracting COVID-19, while those with blood type O are less likely to test positive for the virus. It has also been identified as an extremely rare side effect of certain COVID-19 vaccines. A transcript of the podcast is below the summary. Chills. However, they did not find strong evidence for a relationship between blood group and risk of intubation or death. Blood types are split up into four major groups, all dependent on the presence or absence of two specific antigens on the surface of the blood: A and B, according to the American Red Cross. Black colleagues share their reasons for getting the COVID-19 vaccines, 7 steps to prepare for your COVID-19 vaccines, COVID-19 and Its Cardiovascular Impact Rapid Response Grant.
does blood type affect covid vaccine side effects